\u0627\u0644\u062c\u064a\u0631\u064a\u0627\u0646 \u0627\u0643\u0633\u0628\u0631\u0633: \u0642\u062f \u064a\u0632\u064a\u062f \u0623\u062d\u062f \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0634\u0627\u064a \u0627\u0644\u0623\u062e\u0636\u0631 \u0645\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 53 (p53)\u060c \u0648\u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u0637\u0628\u064a\u0639\u064a \u0645\u0636\u0627\u062f \u0644\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u064a\u064f\u0639\u0631\u0641 \u0628\u0627\u0633\u0645 “\u062d\u0627\u0631\u0633 \u0627\u0644\u062c\u064a\u0646\u0648\u0645” \u0648”\u0645\u062b\u0628\u0637 \u0627\u0644\u0623\u0648\u0631\u0627\u0645”.<\/strong><\/p>\n

\u0648\u064a\u0639\u0631\u0641 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 53 \u0628\u0642\u062f\u0631\u062a\u0647 \u0639\u0644\u0649 \u0625\u0635\u0644\u0627\u062d \u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0623\u0648 \u062a\u062f\u0645\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629. \u0648\u0646\u0634\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u062d\u062f\u064a\u062b\u0629 \u0641\u064a \u0645\u062c\u0644\u0629 Nature Communications\u060c \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0645\u0628\u0627\u0634\u0631 \u0628\u064a\u0646 p53 \u0648\u0645\u0631\u0643\u0628 \u0627\u0644\u0634\u0627\u064a \u0627\u0644\u0623\u062e\u0636\u0631 epigallocatechin gallate\u060c \u0623\u0648 \u0643\u0645\u0627 \u064a\u0639\u0631\u0641 \u0627\u062e\u062a\u0635\u0627\u0631\u0627 \u0628\u0627\u0633\u0645 EGCG\u060c \u0645\u0627 \u064a\u062b\u064a\u0631 \u0647\u062f\u0641\u0627 \u062c\u062f\u064a\u062f\u0627 \u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0633\u0631\u0637\u0627\u0646.<\/p>\n

\u0642\u0627\u0644 \u062a\u0634\u0648\u0646\u064a\u0648 \u0648\u0627\u0646\u063a\u060c \u0627\u0644\u0628\u0627\u062d\u062b \u0627\u0644\u0645\u0634\u0627\u0631\u0643 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0648\u0623\u0633\u062a\u0627\u0630 \u0627\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0641\u064a \u0645\u0639\u0647\u062f Rensselaer Polytechnic: “\u062c\u0632\u064a\u0626\u0627\u062a p53 \u0648EGCG \u0645\u062b\u064a\u0631\u0629 \u0644\u0644\u063a\u0627\u064a\u0629. \u062a\u0645 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a p53 \u0641\u064a \u0623\u0643\u062b\u0631 \u0645\u0646 50% \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0634\u0631\u064a\u060c \u0628\u064a\u0646\u0645\u0627 EGCG \u0647\u0648 \u0645\u0636\u0627\u062f \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0641\u064a \u0627\u0644\u0634\u0627\u064a \u0627\u0644\u0623\u062e\u0636\u0631\u060c \u0648\u0647\u0648 \u0645\u0634\u0631\u0648\u0628 \u0634\u0627\u0626\u0639 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u0639\u0627\u0644\u0645 .. \u0648\u0648\u062c\u062f\u0646\u0627 \u0627\u0644\u0622\u0646 \u0623\u0646 \u0647\u0646\u0627\u0643 \u062a\u0641\u0627\u0639\u0644\u0627 \u0645\u0628\u0627\u0634\u0631\u0627 \u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641 \u0633\u0627\u0628\u0642\u0627 \u0628\u064a\u0646 \u0627\u0644\u0627\u062b\u0646\u064a\u0646\u060c \u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0645\u0633\u0627\u0631 \u062c\u062f\u064a\u062f \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646. \u0648\u064a\u0633\u0627\u0639\u062f \u0639\u0645\u0644\u0646\u0627 \u0641\u064a \u0634\u0631\u062d \u0643\u064a\u0641 \u0623\u0646 EGCG \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u062a\u0639\u0632\u064a\u0632 \u0646\u0634\u0627\u0637 p53 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0645\u0627 \u064a\u0641\u062a\u062d \u0627\u0644\u0628\u0627\u0628 \u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0628\u0645\u0631\u0643\u0628\u0627\u062a \u0634\u0628\u064a\u0647\u0629 \u0628\u0640 EGCG”.<\/p>\n

\u0648\u064a\u0639\u062a\u0628\u0631 \u0648\u0627\u0646\u063a\u060c \u0627\u0644\u0639\u0636\u0648 \u0641\u064a \u0645\u0631\u0643\u0632 Rensselaer Polytechnic \u0644\u0644\u062a\u0642\u0646\u064a\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0648\u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u062a\u062e\u0635\u0635\u0627\u062a\u060c \u062e\u0628\u064a\u0631\u0627 \u0641\u064a \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0637\u064a\u0641\u064a \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0646\u0648\u0648\u064a \u0644\u062f\u0631\u0627\u0633\u0629 \u0622\u0644\u064a\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0641\u064a \u0623\u0645\u0631\u0627\u0636 \u0623\u0644\u0632\u0647\u0627\u064a\u0645\u0631 \u0648\u0627\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 p53\u060c \u0627\u0644\u0630\u064a \u0648\u0635\u0641\u0647 \u0628\u0623\u0646\u0647 “\u0623\u0647\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0625\u0646\u0633\u0627\u0646”.
\n\u0648\u064a\u062d\u062a\u0648\u064a P53 \u0639\u0644\u0649 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0648\u0642\u0641 \u0646\u0645\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u0644\u0633\u0645\u0627\u062d \u0628\u0625\u0635\u0644\u0627\u062d \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u0648\u062a\u0641\u0639\u064a\u0644 \u0625\u0635\u0644\u0627\u062d \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a\u060c \u0648\u0627\u0644\u0628\u062f\u0621 \u0641\u064a \u0627\u0644\u0645\u0648\u062a \u0627\u0644\u0645\u0628\u0631\u0645\u062c \u0644\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u062d\u064a\u0629\u060c \u0648\u064a\u0633\u0645\u0649 \u0627\u0644\u0627\u0633\u062a\u0645\u0627\u062a\u0629\u060c \u0625\u0630\u0627 \u062a\u0639\u0630\u0631 \u0625\u0635\u0644\u0627\u062d \u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a.<\/p>\n

\u0648\u0623\u062d\u062f \u0637\u0631\u0641\u064a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0627\u0633\u0645 \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0637\u0631\u0641\u064a N\u060c \u0644\u0647 \u0634\u0643\u0644 \u0645\u0631\u0646\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a\u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u064a \u0648\u0638\u0627\u0626\u0641 \u0639\u062f\u064a\u062f\u0629 \u062d\u0633\u0628 \u062a\u0641\u0627\u0639\u0644\u0647 \u0645\u0639 \u062c\u0632\u064a\u0626\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629.<\/p>\n

\u0648\u064a\u0648\u0635\u0641 EGCG \u0628\u0623\u0646\u0647 \u0623\u062d\u062f \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629\u060c \u0645\u0627 \u064a\u0639\u0646\u064a \u0623\u0646\u0647 \u064a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u0627\u0644\u062a\u0631\u0627\u062c\u0639 \u0639\u0646 \u0627\u0644\u0636\u0631\u0631 \u0634\u0628\u0647 \u0627\u0644\u0645\u0633\u062a\u0645\u0631 \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u0645\u062b\u064a\u0644 \u0627\u0644\u063a\u0630\u0627\u0626\u064a \u0644\u0644\u0623\u0643\u0633\u062c\u064a\u0646. \u0648\u064a\u0648\u062c\u062f \u0628\u0648\u0641\u0631\u0629 \u0641\u064a \u0627\u0644\u0634\u0627\u064a \u0627\u0644\u0623\u062e\u0636\u0631\u060c \u0643\u0645\u0627 \u064a\u062a\u0645 \u062a\u0639\u0628\u0626\u0629 EGCG \u0643\u0645\u0643\u0645\u0644 \u0639\u0634\u0628\u064a.<\/p>\n

\u0648\u0648\u062c\u062f \u0641\u0631\u064a\u0642 \u0648\u0627\u0646\u063a \u0623\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u064a\u0646 EGCG \u0648p53 \u064a\u062d\u0627\u0641\u0638 \u0639\u0644\u0649 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0646 \u0627\u0644\u062a\u062f\u0647\u0648\u0631. \u0648\u0639\u0627\u062f\u0629\u060c \u0628\u0639\u062f \u0625\u0646\u062a\u0627\u062c\u0647 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645\u060c \u064a\u062a\u062d\u0644\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 p53 \u0628\u0633\u0631\u0639\u0629 \u0639\u0646\u062f\u0645\u0627 \u064a\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0637\u0631\u0641\u064a N \u0645\u0639 \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u0633\u0645\u0649 MDM2. \u0648\u0647\u0630\u0647 \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u0645\u0646\u062a\u0638\u0645\u0629 \u0644\u0644\u0625\u0646\u062a\u0627\u062c \u0648\u0627\u0644\u062a\u062f\u0647\u0648\u0631 \u062a\u062d\u0645\u0644 \u0645\u0633\u062a\u0648\u064a\u0627\u062a p53 \u0639\u0646\u062f \u062b\u0627\u0628\u062a \u0645\u0646\u062e\u0641\u0636.<\/p>\n

\u0648\u0642\u0627\u0644 \u0648\u0627\u0646\u063a: “\u0643\u0644 \u0645\u0646 EGCG \u0648MDM2 \u0645\u0631\u062a\u0628\u0637\u0627\u0646 \u0641\u064a \u0646\u0641\u0633 \u0627\u0644\u0645\u0643\u0627\u0646 \u0639\u0644\u0649 p53\u060c \u0648\u0647\u0648 \u0627\u0644\u0645\u062c\u0627\u0644 \u0627\u0644\u0637\u0631\u0641\u064a N\u060c \u0644\u0630\u0627 \u0641\u0625\u0646 EGCG \u064a\u062a\u0646\u0627\u0641\u0633 \u0645\u0639 MDM2. \u0648\u0639\u0646\u062f\u0645\u0627 \u064a\u0631\u062a\u0628\u0637 EGCG \u0628\u0640 p53\u060c \u0644\u0627 \u064a\u062a\u0645 \u062a\u062d\u0644\u0644 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0646 \u062e\u0644\u0627\u0644 MDM2\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u0641\u0625\u0646 \u0645\u0633\u062a\u0648\u0649 p53 \u0633\u064a\u0632\u062f\u0627\u062f \u0645\u0639 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0645\u0628\u0627\u0634\u0631 \u0645\u0639 EGCG\u060c \u0648\u0647\u0630\u0627 \u064a\u0639\u0646\u064a \u0623\u0646 \u0647\u0646\u0627\u0643 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 p53 \u0644\u0648\u0638\u064a\u0641\u0629 \u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0633\u0631\u0637\u0627\u0646. \u0648\u0647\u0630\u0627 \u062a\u0641\u0627\u0639\u0644 \u0645\u0647\u0645 \u0644\u0644\u063a\u0627\u064a\u0629”.<\/p>\n

\u0627\u0644\u0645\u0635\u062f\u0631: medicalxpress<\/p>\n","protected":false},"excerpt":{"rendered":"

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